The emerging role of insulin-like growth factors in testis development and function

Basic and Clinical Andrology

Richard J Griffeth¹  Vanessa Bianda¹  Serge Nef¹ 

[1] iGE3, Institute of Genetics and Genomics of Geneva, University of Geneva, Geneva, Switzerland

关键词: Testis;    Sex determination;    Spermatogenesis;    Leydig cells;    Sertoli cells;    Insulin;    IGF-II;    IGF-I;   

Others  :  1083960
DOI  :  10.1186/2051-4190-24-12

 received in 2014-06-19, accepted in 2014-07-28,  发布年份 2014

【 摘 要 】

The insulin-like family of growth factors (IGFs) – composed of insulin, and insulin-like growth factors I (IGF1) and II (IGF2) – provides essential signals for the control of testis development and function. In the testis, IGFs act in an autocrine-paracrine manner but the extent of their actions has been underestimated due to redundancies at both the ligand and receptor levels, and the perinatal lethality of constitutive knockout mice. This review synthesizes the current understanding of how the IGF system regulates biological processes such as primary sex determination, testis development, spermatogenesis and steroidogenesis, and highlights the questions that remain to be explored.

【 授权许可】

   
2014 Griffeth et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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