Effect of sodium tripolyphosphate concentration and simulated gastrointestinal fluids on release profile of paracetamol from chitosan microsphere

Quality in Research: International Symposium on Materials, Metallurgy, and Chemical Engineering

材料科学;冶金学;化学工业

Mulia, Kamarza^1 ; Andrie^1 ; Krisanti, Elsa A.^1

Chemical Engineering Department, Faculty of Engineering, Universitas Indonesia, Depok

16424, Indonesia^1

关键词: Chitosan microspheres;    Controlled release;    Drug administration;    Encapsulation efficiency;    Sodium tripolyphosphate;    Solution concentration;    Tripolyphosphate solution;    Zero-order release;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/316/1/012028/pdf
DOI  :  10.1088/1757-899X/316/1/012028

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

The problem to overcome in oral drug administration is the significant pH changes present in the human digestive system. In this study, ionotropic gelation method employing 2-8% (w/v) tripolyphosphate solutions were used to crosslink chitosan microspheres for a controlled release of paracetamol as a model drug. The release profiles of paracetamol from chitosan microspheres were determined using simulated gastrointestinal fluids having pH values of 1.2, 6.8, and 7.4. The results showed that the paracetamol loading and the encapsulation efficiency values increased with increasing concentration of tripolyphosphate solutions used in the preparation step. Paracetamol released at pH 1.2 and 6.8 buffer solutions was significantly higher than that at pH 7.4; also, more paracetamol was released in the presence of α-amylase and β-glucosidase enzymes. The release profiles showed zero-order release behaviour up to 8 hours where the highest drug release was 39% of the paracetamol loaded in the chitosan microspheres, indicating a strong crosslinking between chitosan and TPP anions. The relatively low accumulated drug release could be compensated by employing suitable enzymes, lower TPP solution concentration, and addition of other biodegradable polymer to reduce the TPP crosslink.