Pluronic F127/chitosan blend microspheres for mucoadhesive drug delivery

1st International Conference on New Material and Chemical Industry

材料科学;化学工业

Gu, W.Z.^1 ; Hu, X.F.^1

College of Life Science, Zhejiang Chinese Medical University, Hangzhou

310053, China^1

关键词: Chitosan microspheres;    Cross-linking process;    Experimental conditions;    Glutaraldehydes;    Physical stability;    Protein absorption;    Swelling capacities;    Traditional Chinese Medicine;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/167/1/012001/pdf
DOI  :  10.1088/1757-899X/167/1/012001

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

Pluronic F127/chitosan blend microspheres were prepared via emulsification and cross-linking process using glutaraldehyde as a cross-linker. Compared with chitosan microspheres fabricated under the same experimental conditions, blend microspheres exhibited better physical stability and higher swelling capacity. Puerarin, a traditional Chinese medicine, was incorporated into microparticlesas the model drug. The in vitro release of puerarin from blend microspheres was reduced because of the improved compatibility of the drug with the matrices. According to the results from in vitro adhesion experiments, mucoadhesive behavior of blend microspheres on a mucosa-like surface was similar to that of chitosan microspheres, despite their good ability of anti-protein absorption in solution.