Synthesis and Characterization of Hyaluronic Acid Modified Colloidal Mesoporous Silica Nanoparticles

5th Annual International Conference on Material Science and Engineering

Zhang, Wenbiao^1,2,3 ; Wang, Yu^1,2,3 ; Li, Zhen^1,2,3 ; Wang, Wanxia^1,2,3 ; Sun, Honghao^1,2,3 ; Liu, Mingxing^1,2,3

Key Laboratory of Fermentation Engineering (Ministry of Education, Hubei University of Technology, Wuhan

430068, China^1

Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei University of Technology, Wuhan

430068, China^2

Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan

430068, China^3

关键词: Amino-functionalized mesoporous silicas;    Drug delivery system;    External surfaces;    Fourier transform infra red (FTIR) spectroscopy;    Mesoporous silica nanoparticles;    Negatively charged;    Spherical morphologies;    Synthesis and characterizations;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/275/1/012009/pdf
DOI  :  10.1088/1757-899X/275/1/012009

来源: IOP

【 摘 要 】

The colloidal mesoporous silica nanoparticles functionalized with hyaluronic acid (CMS-HA) were successfully synthesized by grafting hyaluronic acid onto the external surface of the amino-functionalized mesoporous silica nanoparticles (CMS-NH2). Moreover, the paticle properties of CMS-HA were characterized by fourier transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS) and transmission electron microscopy (TEM). The nanomaterials were negatively charged and had a relatively uniform spherical morphology with about 100 nm in diameter, which could make it more compatible with blood. So the results suggested that the CMS-HA might be a critical nanomaterial for applying in target drug delivery system.