Characterization of konjac glucomannan-gelatin IPN physical hydrogel scaffold

4th International Conference on Advanced Composite Materials and Manufacturing Engineering 2017

材料科学;化学

Chen, Xiliang^1 ; Chen, Qinghua^1 ; Yan, Tingting^1 ; Liu, Jinkun^1

School of Materials Science and Engineering, Kunming University of Science and Technology, Kunming, China^1

关键词: Cartilage tissue engineering;    Fourier transform infrared spectra;    Freeze drying method;    Gelatin molecules;    Hydrogel scaffolds;    Konjac glucomannan;    Structures and properties;    X-ray diffraction method;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/207/1/012029/pdf
DOI  :  10.1088/1757-899X/207/1/012029

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

A novel IPN hydrogel scaffold is prepared by freeze-drying method, in which konjac galactomannan (KGM) and gelatin are physically crosslinked respectively. This scaffold is thermostable, and the structure of this scaffold is analysed by scanning electron microscope, Fourier transform infrared spectrum, and X-ray diffraction method. The FT-IR results show that hydrogen bonds are formed between KGM and gelatin molecules, which hinder the formation of their respective crosslinking. This is consistent with the XRD results that the crystallinity gets lower in the IPN gels compared with pure gelatin and KGM gels. The morphologies of freeze-dried hydrogels are observed by SEM and the mechanical properties of the scaffolds are tested to analyse the relationship between the structures and properties. Although this novel IPN hydrogel is physical gel, it shows rubber-like performance as chemical gels. And it is nontoxic, so it can be used as the scaffold for cartilage tissue engineering that embedded in human bodies.