Possibilities of the method of irreversible electroporation in treatment of the local and widespread pancreatic cancer

1st International Symposium 'Physics, Engineering and Technologies for Bio-Medicine'

医药卫生;物理学;工业技术

Anaskin, S.G.^1 ; Ivanov, Yu.V.^1 ; Panchenkov, D.N.^2 ; Chertyuk, V.B.^3 ; Astakhov, D.A.^4 ; Nechunayev, A.A.^4 ; Geraskin, V.S.^1 ; Fedotova, T.Y.^1

National Research Nuclear University, MEPhI, Moscow, Russia^1

Department of Endoscopic Surgery, SEI HPE MSMSU Them. A. I. Evdokimov, Moscow, Russia^2

Institute of Emergency Children's Surgery and Traumatology, Moscow, Russia^3

Federal Scientific Clinical Center, FMBA of Russia, Moscow, Russia^4

关键词: Cellular membranes;    Current structure;    Efficiency of new technologies;    Histological structure;    International experiences;    Morphological research;    Pancreatic cancers;    Surgical treatment;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/784/1/012054/pdf
DOI  :  10.1088/1742-6596/784/1/012054

来源: IOP

【 摘 要 】

Methods of a local destruction of tumors didn't find till today wide circulation in treatment of patients with formations of the pancreas (P). It is bound to features of blood supply, anatomical and histological structure of PZh, and also a large number of complications and a recurrence. The technique of the irreversible elektroporation (IE) represents a new unique method of not thermal ablyation at which impact on tissues is carried out by short electric impulses of high voltage (to 3 kV) that involves irreversible rising of permeability of cellular membranes and death of cells. The optimum mechanism of rising of permeability of a cellular membrane electric impulses concerning their frequency or repetitions is yet not up to the end clear; it is recognized that outcomes depend on amplitude, duration and number of impulses. Influence has to be synchronized with a cordial rhythm in order to avoid development of an arrhythmia. Existence at the patient of an arrhythmia and the artificial driver of a rhythm is contraindication to carrying out an elektroporation. We have experience of use of a technique for 18 patients with a locally-spread pancreatic cancer. It was succeeded to reflect the main advantages of a new technique in our experience, such as comparative simplicity of workmanship, safety for vascular and pro-current structures, the minimum impact on function of a pancreas. Efficiency of a destruction is proved to ultrasonic, computer and morphological researches in the postoperative period. The maximum term of observation made 19 months. Though exact indications to use of NE still accurately aren't defined, the international experience and the first own data allow to state efficiency of new technology in palliative surgical treatment of perivascular tumors of a pancreas, and also its safety.