When the clock strikes: Modeling the relation between circadian rhythms and cardiac arrhythmias

27th IUPAP Conference on Computational Physics

物理学;计算机科学

Seenivasan, Pavithraa^1,2 ; Menon, Shakti N.^1 ; Sridhar, S.^1,3 ; Sinha, Sitabhra^1

Institute of Mathematical Sciences, C. I. T. Campus, Taramani, Chennai

600 113, India^1

Molecular Biophysics Unit, Indian Institute of Science, Bangalore

560 012, India^2

Department of Physics and Astronomy, Ghent University, St. Pietersnieuwstraat 33, Ghent

9000, Belgium^3

关键词: Conductance properties;    Electrical activities;    Intracellular levels;    Physiological activity;    Statistical relationship;    Sudden cardiac deaths;    Temporal oscillations;    Ventricular fibrillation;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/759/1/012021/pdf
DOI  :  10.1088/1742-6596/759/1/012021

学科分类：计算机科学（综合）

来源: IOP

【 摘 要 】

It has recently been observed that the occurrence of sudden cardiac death has a close statistical relationship with the time of day, viz., ventricular fibrillation is most likely to occur between 12am-6am, with 6pm-12am being the next most likely period. Consequently there has been significant interest in understanding how cardiac activity is influenced by the circadian clock, i.e., temporal oscillations in physiological activity with a period close to 24 hours and synchronized with the day-night cycle. Although studies have identified the genetic basis of circadian rhythm at the intracellular level, the mechanisms by which they influence cardiac pathologies are not yet fully understood. Evidence has suggested that diurnal variations in the conductance properties of ion channel proteins that govern the excitation dynamics of cardiac cells may provide the crucial link. In this paper, we investigate the relationship between the circadian rhythm as manifested in modulations of ion channel properties and the susceptibility to cardiac arrhythmias by using a mathematical model that describes the electrical activity in ventricular tissue. We show that changes in the channel conductance that lead to extreme values for the duration of action potentials in cardiac cells can result either in abnormally high-frequency reentrant activity or spontaneous conduction block of excitation waves. Both phenomena increase the likelihood of wavebreaks that are known to initiate potentially life- threatening arrhythmias. Thus, disruptive cardiac excitation dynamics are most likely to occur in time-intervals of the day-night cycle during which the channel properties are closest to these extreme values, providing an intriguing relation between circadian rhythms and cardiac pathologies.