The chemical structures and biological activities of indole diterpenoids

Natural Products and Bioprospecting

Review

Pengchao Wang¹  Jingwen Niu¹  Chengwei Liu¹  Jianzhao Qi²  Jin-ming Gao³ 

[1] Key Laboratory for Enzyme and Enzyme-Like Material Engineering of Heilongjiang, College of Life Science, Northeast Forestry University, 150040, Harbin, Heilongjiang, China;Key Laboratory for Enzyme and Enzyme-Like Material Engineering of Heilongjiang, College of Life Science, Northeast Forestry University, 150040, Harbin, Heilongjiang, China;Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, 712100, Yangling, Shaanxi, China;Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, 712100, Yangling, Shaanxi, China;

关键词: Indole diterpenoids;    Structural classification;    Physiological activity;    Fungus;   

DOI  :  10.1007/s13659-022-00368-7

 received in 2022-10-14, accepted in 2022-12-08,  发布年份 2022

来源: Springer

【 摘 要 】

Indole diterpenoids (IDTs) are an essential class of structurally diverse fungal secondary metabolites, that generally appear to be restricted to a limited number of fungi, such as Penicillium, Aspergillus, Claviceps, and Epichloe species, etc. These compounds share a typical core structure consisting of a cyclic diterpene skeleton of geranylgeranyl diphosphate (GGPP) and an indole ring moiety derived from indole-3-glycerol phosphate (IGP). 3-geranylgeranylindole (3-GGI) is the common precursor of all IDTs. On this basis, it is modified by cyclization, oxidation, and prenylation to generate a large class of compounds with complex structures. These compounds exhibit antibacterial, anti-insect, and ion channel inhibitory activities. We summarized 204 compounds of IDTs discovered from various fungi over the past 50 years, these compounds were reclassified, and their biological activities were summarized. This review will help to understand the structural diversity of IDTs and provide help for their physiological activities.Graphical Abstract

【 授权许可】

CC BY   
© The Author(s) 2023. corrected publication 2023

【 图 表 】

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