What is the impact of Silicon Carbide nanoparticles to the mineral composition of rat lungs? A PIXE-μPIXE comparative study

4th International Conference on Safe Production and Use of Nanomaterials

Lozano, O.^1 ; Colaux, J.L.^2 ; Laloy, J.^3 ; Dogné, J.M.^3 ; Lucas, S.^1

Research Centre for the Physics of Matter and Radiation (PMR), Namur Nanosafety Center (NNC), NAmur Research Institute for LIfe Sciences (NARILIS), University of Namur (UNamur), Rue de Bruxelles 61, Namur

B-5000, Belgium^1

University of Surrey, Ion Beam Centre, Guildford

GU2 7XH, United Kingdom^2

Department of Pharmacy, Namur Nanosafety Center (NNC), NAmur Research Institute for LIfe Sciences (NARILIS), University of Namur (UNamur), Rue de Bruxelles 61, Namur

B-5000, Belgium^3

关键词: Carbide nanoparticles;    Comparative studies;    Global perspective;    Mineral composition;    Mineral content;    Nanoaerosol;    Particle induced X-ray emission;    Silicon carbides (SiC);   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/617/1/012016/pdf
DOI  :  10.1088/1742-6596/617/1/012016

来源: IOP

【 摘 要 】

The exposure to nanomaterials can yield changes in the mineral composition of tissues which may have long term health repercussions. In this study, the changes in mineral composition of rat lungs, exposed to a nanoaerosol of silicon carbide (SiC), has been studied by means of global and local ion beam probes with the Particle-Induced X-ray Emission (PIXE) technique, measuring the whole lung contents and selected areas where SiC was found, respectively. It was found that from a global perspective there is a small decrease in the mineral contents (phosphorous, sulphur, chlorine and potassium) of the lung except for Ca, while locally these mineral contents tend fluctuate.