Characterization of a reusable PRESAGE? 3D dosimeter

8th International Conference on 3D Radiation Dosimetry

Juang, T.^1,2 ; Adamovics, J.^3,4 ; Oldham, M.^2

Medical Physics Graduate Program, Duke University, Durham

NC, United States^1

Duke University Medical Center, Durham

NC, United States^2

Rider University, Lawerenceville

NJ, United States^3

Heuris Pharma, LLC, 412 Sunset Rd., Skillman

NJ

08558, United States^4

关键词: 3d dosimeters;    Dose distributions;    Dose response;    Exponential rates;    Gamma analysis;    High resolution;    Optical clearing;    Radiation-induced;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/573/1/012039/pdf
DOI  :  10.1088/1742-6596/573/1/012039

来源: IOP

【 摘 要 】

This study investigates a reusable PRESAGE® 3D dosimeter (Presage-RU), which would improve cost-effectiveness and facilitate wider implementation of comprehensive, high resolution 3D dosimetry. Small (1x1x4.5 cm) and large (8 cm diameter, 4.5 cm length) sample dosimeters were irradiated multiple times to characterize dose response (i.e. radiation-induced change in optical density (ΔOD)), optical clearing rate, and dose distribution stability. Presage- RU exhibited an initial dose response sensitivity of 0.0119 ΔOD/(cm-Gy), a reduction in response with subsequent irradiations, and a small, permanent ΔOD (∼1-6% of initial signal) following each irradiation. Dosimeters optically cleared at an exponential rate (average T1/224.8±3.6 h), and were effectively cleared after ∼5-8 days. 3D gamma analysis (3%/3mm, 10% dose threshold) of a 4-field box plan applied to the large dosimeter showed good agreement following initial irradiation (96.6% passing), but a reduction in passing rate (89.1% passing) with subsequent irradiation. Further study is warranted to fully assess and quantify the performance of Presage-RU for repeat irradiations.