A Parallel 2D Numerical Simulation of Tumor Cells Necrosis by Local Hyperthermia

2nd International Conference on Mathematical Modeling in Physical Sciences 2013

物理学;数学

Reis, R.F.^1 ; Loureiro, F.S.^1 ; Lobosco, M.^1

Department of Computer Science, Federal University of Juiz de Fora, Brazil^1

关键词: 2-D numerical simulation;    Alternating magnetic field;    Explicit finite difference method;    Improve performance;    Magnetic nano-particles;    Pennes bioheat transfer equations;    Threshold temperatures;    Tumor ablation;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/490/1/012138/pdf
DOI  :  10.1088/1742-6596/490/1/012138

来源: IOP

【 摘 要 】

Hyperthermia has been widely used in cancer treatment to destroy tumors. The main idea of the hyperthermia is to heat a specific region like a tumor so that above a threshold temperature the tumor cells are destroyed. This can be accomplished by many heat supply techniques and the use of magnetic nanoparticles that generate heat when an alternating magnetic field is applied has emerged as a promise technique. In the present paper, the Pennes bioheat transfer equation is adopted to model the thermal tumor ablation in the context of magnetic nanoparticles. Numerical simulations are carried out considering different injection sites for the nanoparticles in an attempt to achieve better hyperthermia conditions. Explicit finite difference method is employed to solve the equations. However, a large amount of computation is required for this purpose. Therefore, this work also presents an initial attempt to improve performance using OpenMP, a parallel programming API. Experimental results were quite encouraging: speedups around 35 were obtained on a 64-core machine.