Diagnostic test pepsinogen I and combination with tumor marker CEA in gastric cancer

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Sembiring, J.^1,3 ; Sarumpaet, K.^2,3 ; Ganie, R.A.^2,3

Division of Gastroentero-Hepatology, Departement of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia^1

Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia^2

Haji Adam Malik General Hospital, Medan, Indonesia^3

关键词: Carcinoembryonic antigen;    Colorectal cancer;    Confidence interval;    Diagnostic accuracy;    Diagnostic tests;    Gastric cancers;    Management options;    Tumor markers;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012138/pdf
DOI  :  10.1088/1755-1315/125/1/012138

来源: IOP

【 摘 要 】

Gastric cancer (GC) is the fifth leading cause of cancer and the third leading cause of cancer-related mortality globally. Human pepsinogens (HP) are considered promising serological biomarkers for the screening of atrophic gastritis (AG) and GC. HP are biochemically and immunochemically classified into two groups: pepsinogen I (PG I) and PG II. Carcinoembryonic antigen (CEA) is a glycoprotein, which is present in normal mucosal cells but increased amounts are associated with adenocarcinoma, especially colorectal cancer. CEA in combination with other tumour markers can be used in pre-operative staging and thereby assist in the planning of the type of surgery required and future management options. The purpose of this study was to diagnose test PG I and combination with tumor marker CEA in 32 patients suspected with GC. There was a significant difference in levels of CEA between GC group with non-GC with a value p