Synthesis of 2-chloro-4-(3-nitrophenoxy) thieno [3, 2-d] pyrimidine

2018 4th International Conference on Environmental Science and Material Application

生态环境科学;材料科学

Zhou, Zhihui^1 ; Wang, Caolin^1 ; Xiao, Zhen^1 ; Yang, Qi^1 ; Xu, Shan^1

School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang

330013, China^1

关键词: Anticancer drug;    Ms spectrum;    Nucleophilic substitutions;    Small molecules;    Synthetic methods;    Target compound;    Total yield;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/252/2/022091/pdf
DOI  :  10.1088/1755-1315/252/2/022091

来源: IOP

【 摘 要 】

2, 4-dichloro-6-(3-nitrophenoxy) pyrimidine is an important intermediate of small molecule anticancer drugs. In this work, a rapid synthetic method for target compounds was established. Compound (4) was synthesized from methyl 3-aminothiophene-2-carboxylate and urea through three steps including cyclization, chlorination and nucleophilic substitution. The structure of the target compound was confirmed by 1H NMR and MS spectrum. Furthermore, the synthetic method was optimized. The total yield of the three steps was 42.4%.