会议论文详细信息
2018 4th International Conference on Environmental Science and Material Application | |
Synthesis of 2-chloro-4-(3-nitrophenoxy) thieno [3, 2-d] pyrimidine | |
生态环境科学;材料科学 | |
Zhou, Zhihui^1 ; Wang, Caolin^1 ; Xiao, Zhen^1 ; Yang, Qi^1 ; Xu, Shan^1 | |
School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang | |
330013, China^1 | |
关键词: Anticancer drug; Ms spectrum; Nucleophilic substitutions; Small molecules; Synthetic methods; Target compound; Total yield; | |
Others : https://iopscience.iop.org/article/10.1088/1755-1315/252/2/022091/pdf DOI : 10.1088/1755-1315/252/2/022091 |
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来源: IOP | |
【 摘 要 】
2, 4-dichloro-6-(3-nitrophenoxy) pyrimidine is an important intermediate of small molecule anticancer drugs. In this work, a rapid synthetic method for target compounds was established. Compound (4) was synthesized from methyl 3-aminothiophene-2-carboxylate and urea through three steps including cyclization, chlorination and nucleophilic substitution. The structure of the target compound was confirmed by 1H NMR and MS spectrum. Furthermore, the synthetic method was optimized. The total yield of the three steps was 42.4%.
【 预 览 】
Files | Size | Format | View |
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Synthesis of 2-chloro-4-(3-nitrophenoxy) thieno [3, 2-d] pyrimidine | 160KB | download |