Synthesis of 2-chloro-N, N-diethyl-7-fluoroquinazolin-4-amine

2018 4th International Conference on Environmental Science and Material Application

生态环境科学;材料科学

Zhou, Zhihui^1 ; Wang, Caolin^1 ; Xiao, Zhen^1 ; Yang, Qi^1 ; Xu, Shan^1

School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang

330013, China^1

关键词: Anticancer drug;    Ms spectrum;    Nucleophilic substitutions;    Small molecules;    Synthetic methods;    Target compound;    Total yield;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/252/2/022090/pdf
DOI  :  10.1088/1755-1315/252/2/022090

来源: IOP

【 摘 要 】

7-fluoroquinazoline-2, 4-diol is an important intermediate of small molecule anticancer drugs. In this work, a rapid synthetic method for target compounds was established. Compound (4) was synthesized from 2-amino-4-fluoro benzoic acid and urea through three steps including cyclization, chlorination and nucleophilic substitution. The structure of the target compound was confirmed by H NMR and MS spectrum. Furthermore, the synthetic method was optimized. The total yield of the three steps was 51%.