A pharmacist check of patients’ infection-related condition prior to drug preparation reduces anticancer drug wastage after mixing: a retrospective study

Journal of Pharmaceutical Policy and Practice

Research

Yuto Yamada¹  Hirotoshi Iihara¹  Akio Suzuki²  Ryo Kobayashi²  Hirotsugu Yamada³  Hiroyuki Tanaka⁴ 

[1] Department of Pharmacy, Gifu University Hospital, 1-1 Yanagido, 501-1194, Gifu, Japan;Department of Pharmacy, Gifu University Hospital, 1-1 Yanagido, 501-1194, Gifu, Japan;Laboratory of Advanced Medical Pharmacy, Gifu Pharmaceutical University, Gifu, Japan;Department of Pharmacy, Gifu University Hospital, 1-1 Yanagido, 501-1194, Gifu, Japan;United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan;United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan;Laboratory of Immunobiology, Department of Biofunctional Analysis, Gifu Pharmaceutical University, Gifu, Japan;

关键词: Anticancer drug;    Drug wastage;    Cost;    Pharmacist;    Infection;   

DOI  :  10.1186/s40545-023-00518-3

 received in 2022-01-04, accepted in 2023-01-07,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundWe previously reported that a standardized pharmacist check of medical orders related to the administration criteria of anticancer drugs prior to preparation of injectable anticancer drugs was useful for reducing drug wastage after mixing. To further reduce anticancer drug wastage after preparation, we added a pharmacist check of patients' infection-related condition to the previous protocol and assessed the effectiveness of the modified protocol for reducing injectable anticancer drug wastage.MethodsIn addition to the administration criteria of anticancer drugs, patients’ infection-related condition, which was based on a body temperature ≥ 37.5 °C or elevated C-reactive protein (CRP) or white blood cell (WBC) count from baseline, was added to pharmacists’ checklist of items used previously to prepare injectable anticancer drugs. We retrospectively compared the number, type and cost of anticancer drugs discarded after preparation and the reasons for discarding these drugs between pre- and post-protocol modification.ResultsThe rate at which anticancer drugs were discarded after preparation was significantly reduced after introducing the modified protocol compared to the original protocol (0.288% [18/6253] vs. 0.095% [6/6331], P = 0.013). Furthermore, the number of cases for which mixed anticancer agents were discarded because of infection decreased from 11 (fever: n = 8; elevated CRP or WBC: n = 3) to one (elevated CRP: n = 1) a year.ConclusionsIn addition to the standard administration criteria of anticancer drugs, checking patients’ infection-related condition, defined by a body temperature ≥ 37.5 °C or elevated CRP or WBC from baseline, before mixing by the pharmacist is useful for reducing anticancer drug wastage after preparation.

【 授权许可】

CC BY   
© The Author(s) 2023

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