Synthesis of 1-(N, N-dimethyl) amine-2-(o-chlorobenzoyl)-methyl acrylate

2018 4th International Conference on Environmental Science and Material Application

生态环境科学;材料科学

Zhang, Jianqing^1 ; Duan, Yongli^1 ; Xiong, Hehua^1 ; Zhuang, Yingmei^1 ; Tang, Qidong^1

School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang

330013, China^1

关键词: Anticancer drug;    Chloroacetophenone;    Dimethyl carbonate;    Efficient synthesis;    Methyl acrylates;    Ms spectrum;    Nucleophilic substitutions;    Synthesis method;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/252/2/022086/pdf
DOI  :  10.1088/1755-1315/252/2/022086

来源: IOP

【 摘 要 】

1-(N, N-dimethyl) amine-2-(o-chlorobenzoyl)-methyl acrylate is an important intermediate for the many biologically active anticancer drugs. In this research, a rapid and efficient synthesis of compounds 8 was established. Compound 8 consisting of o-chloroacetophenone and dimethyl carbonate was synthesized by two steps including nucleophilic substitution and carbanion reaction. The synthesis method was optimized, and structure was confirmed by 1H NMR and MS spectrum. The synthesis method is optimized. The total yield of the two steps is 63.69%.