PLGA microsphere/P(NIPAAm-co-AAm) hydrogel combination systems for drug delivery

2nd International Workshop on Materials Science and Mechanical Engineering

机械制造;材料科学

Yang, J.^1^2

Chongqing Institution of Higher Learning Center of Forensic Science Engineering and Research, Southwest University of Political Science and Law, Chongqing

401120, China^1

College of Criminal Investigation, Southwest University of Political Science and Law, Chongqing

401120, China^2

关键词: Bovine serum albumins;    Combination systems;    Drug delivery system;    Interconnected porous structure;    PLGA microspheres;    Poly(lactic-co-glycolic acid);    Scanning electronic microscopes;    Sustained release;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/504/1/012013/pdf
DOI  :  10.1088/1757-899X/504/1/012013

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

A combination drug delivery system was successfully prepared by dispersing drugloaded-poly (lactic-co-glycolic acid) (PLGA) microspheres into porous poly (Nisopropylamide-co-acrylamide) P(NIPAAm-co-AAm) hydrogel. Scanning electronic microscope (SEM) studies revealed that PLGA microspheres were encased into the interconnected porous structure of P(NIPAAm-co-AAm) hydrogel. In vitro release of Bovine serum albumin (BSA) from combination system exhibited a lower burst release followed by a slower sustained release as compared to BSA release from the PLGA microspheres and P (NIPAAm-co-AAm) hydrogels alone. These results demonstrated that the combination systems have the potential application in drug delivery.