2nd International Workshop on Materials Science and Mechanical Engineering | |
PLGA microsphere/P(NIPAAm-co-AAm) hydrogel combination systems for drug delivery | |
机械制造;材料科学 | |
Yang, J.^1^2 | |
Chongqing Institution of Higher Learning Center of Forensic Science Engineering and Research, Southwest University of Political Science and Law, Chongqing | |
401120, China^1 | |
College of Criminal Investigation, Southwest University of Political Science and Law, Chongqing | |
401120, China^2 | |
关键词: Bovine serum albumins; Combination systems; Drug delivery system; Interconnected porous structure; PLGA microspheres; Poly(lactic-co-glycolic acid); Scanning electronic microscopes; Sustained release; | |
Others : https://iopscience.iop.org/article/10.1088/1757-899X/504/1/012013/pdf DOI : 10.1088/1757-899X/504/1/012013 |
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学科分类:材料科学(综合) | |
来源: IOP | |
【 摘 要 】
A combination drug delivery system was successfully prepared by dispersing drugloaded-poly (lactic-co-glycolic acid) (PLGA) microspheres into porous poly (Nisopropylamide-co-acrylamide) P(NIPAAm-co-AAm) hydrogel. Scanning electronic microscope (SEM) studies revealed that PLGA microspheres were encased into the interconnected porous structure of P(NIPAAm-co-AAm) hydrogel. In vitro release of Bovine serum albumin (BSA) from combination system exhibited a lower burst release followed by a slower sustained release as compared to BSA release from the PLGA microspheres and P (NIPAAm-co-AAm) hydrogels alone. These results demonstrated that the combination systems have the potential application in drug delivery.
【 预 览 】
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PLGA microsphere/P(NIPAAm-co-AAm) hydrogel combination systems for drug delivery | 864KB | download |