Bioinformatic analysis on pathological association of human aminoacyl-tRNA synthetases and their protein network with neurological diseases

ARS;Neurological disease;mRNA expression profile;DEG;PPI;Network;Gene ontology biological process;NAG;610

융합과학기술대학원 분자의학 및 바이오제약학과 ;

University:서울대학교 대학원

关键词: ARS;    Neurological disease;    mRNA expression profile;    DEG;    PPI;    Network;    Gene ontology biological process;    NAG;    610;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/133415/1/000000140871.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

NAGs) from public databases and the literature and identified 86 and 687 factors as the first- and second-neighbor NAGs, respectively. We retrieved 67 gene expression datasets of 24 neurological diseases from Gene Expression Omnibus (GEO) and ArrayExpress. The gene expression profiles of ARSs/AIMPs and their neighboring NAGs were compared with negative controls (non-NAGs). We obtained P values for each dataset and combined them for each disease. Then, the P values for each disease were combined into a value representing the whole set of 24 neurological diseases. Additionally, we created a subnetwork representing biological processes and P values using the Database for Annotation, Visualization, and Integrated Discovery (DAVID).Quite a few ARSs/AIMPs and first- and second-neighbor NAGs were differentially expressed genes (DEGs) in neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. In summary, 20 human cytosolic ARSs and 3 AIMPs are strongly connected to diverse NAGs and are differentially expressed in neurological diseases, indicating their implication in these diseases.