Vibrational characteristics of brain magnetic resonance elastography

Magnetic resonance imaging;Magnetic resonance elastography;Tissue stiffness;Brain

Johnson, Curtis L. ; Georgiadis ; John G.

关键词: Magnetic resonance imaging;    Magnetic resonance elastography;    Tissue stiffness;    Brain;   

Others  :  https://www.ideals.illinois.edu/bitstream/handle/2142/16225/Johnson_Curtis.pdf?sequence=1&isAllowed=y

美国|英语

来源: The Illinois Digital Environment for Access to Learning and Scholarship

【 摘 要 】

This thesis aims to investigate vibrational characteristics of magnetic resonance elastography (MRE) of the brain.MRE is a promising, non-invasive methodology for the mapping of shear stiffness of the brain.A mechanical actuator shakes the brain and generates shear waves, which are then imaged with a special MRI sequence sensitive to sub-millimeter displacements.This research focuses on exploring the profile of vibrations utilized in brain elastography from the standpoint of ultimately investigating nonlinear behavior of the tissue.The first objective seeks to demonstrate the effects of encoding off-frequency vibrations using standard MRE methodologies.Vibrations of this nature can arise from nonlinearities in the system and contaminate the results of the measurement.The second objective is to probe nonlinearity in the dynamic brain system using MRE.A non-parametric decomposition technique, novel to the MRE field, is introduced and investigated.