High-speed polarization-sensitive optical coherence tomography: toward intraoperative cancer imaging

biomedical imaging;optical coherence tomography;breast cancer;polarization

South, Fredrick A. ; Boppart ; Stephen A.

关键词: biomedical imaging;    optical coherence tomography;    breast cancer;    polarization;   

Others  :  https://www.ideals.illinois.edu/bitstream/handle/2142/46580/Fredrick_South.pdf?sequence=1&isAllowed=y

美国|英语

来源: The Illinois Digital Environment for Access to Learning and Scholarship

【 摘 要 】

Successful treatment of most breast cancers requires surgical removal of the tumor. The current standard-of-care does not provide any tools for real-time assessment of the tumor cavity. Optical coherence tomography (OCT) has previously been developed for real-time intraoperative use in hopes of aiding tumor margin assessment. While there has been much success, it remains difficult to distinguish between normal stroma tissue and breast cancer.Polarization-sensitive optical coherence tomography (PS-OCT) is an extension of OCT that measures both the intensity and polarization of light returning from the tissue. PS-OCT is sensitive to changes in collagen structure and may provide additional contrast between normal and diseased tissue. This thesis reports the development of a real-time PS-OCT system using a high-speed swept-source laser and parallel processing on a graphics processing unit (GPU). Results of a preliminary imaging study are also reported, demonstrating that PS-OCT provides enhanced contrast between previously indistinguishable fibrous stroma and invasive ductal carcinoma (IDC).