SPIO processing in macrophages for MPI: The breast cancer MPI-SNLB-concept

Current Directions in Biomedical Engineering

Finas Dominique¹  Achim Rody²  Janine Stegmann-Frehse²  Benjamin Sauer³  Gereon Hüttmann³  Kerstin Lüdtke-Buzug⁴  Thorsten Buzug⁴ 

[1] Evangelical Hospital Bielefeld, Burgsteig 13, 33617 Bielefeld, Germany, phone [phone], fax [phone];University of Lübeck, Department of Obstetrics and Gynecology, Germany;University of Lübeck, Institute of Biomedical Optics, Germany;University of Lübeck, Institute of Medical Engineering, Germany;

关键词: biomedical imaging;    magnetic particle imaging;    breast cancer;    sentinel-lymphnode-detection;    super paramagnetic iron oxidenano particles;    nano particle detection;    nano particle processing;    safety;    macrophages;    multiphoton microscopy;    transmission electron microscopy;   

DOI  :  10.1515/cdbme-2016-0002

来源: DOAJ

【 摘 要 】

Breast cancer (BC) is the most common cancer in women worldwide. We aim to develop a new sentinel lymph node biopsy (SLNB) method with superparamagnetic iron oxide nanoparticles (SPIOs) and magnetic particle imaging (MPI) in BC to avoid tissue damaging while axillary surgery. As we know from i.v. SPIO application in magnetic resonance imaging (MRI), macrophages (MP) are key role player in processing of SPIOs (e.g. in liver) causing a drop of signal intensity. But, knowledge lacks concerning enrichment processes of SPIOs after injection in breast tissue, the adjacent lymphatic tissues and associated cells, especially in BC and metastatic lymph nodes. We already evaluated the distribution of SPIOs in an in vivo healthy and tumor mouse model. Based on these studies we investigate the processing of the SPIOs in MP.

【 授权许可】

Unknown