A universal miniaturized electrochemical sensing platform and its applications

Biosensor;Portable devices;Electrochemical sensing;Nitrate concentration;White blood cell counting

Zhou, Xiangfei ; Liu ; Gang

关键词: Biosensor;    Portable devices;    Electrochemical sensing;    Nitrate concentration;    White blood cell counting;   

Others  :  https://www.ideals.illinois.edu/bitstream/handle/2142/99246/ZHOU-THESIS-2017.pdf?sequence=1&isAllowed=y

美国|英语

来源: The Illinois Digital Environment for Access to Learning and Scholarship

【 摘 要 】

We have developed a portable universal miniaturized electrochemical sensing platform, which integrates with a microelectronic sensor strip, that can perform various electrochemical and impedance sensing measurements. This sensing platform works as a miniaturized potentiostat that supports a number of potential waveforms such as cyclic voltammetry (CV) and differential pulse voltammetry (DPV), which are the foundations of modern electrochemical research. This thesis first explains the theoretical basis and physical implementation of the sensing system, which covers design of hardware, embedded system and sensing algorithm. The circuit hardware principle is based on the three-electrode system widely used in electrochemistry experiments. Then the thesis discloses several real electrochemical applications that can be conducted using the sensing platform, which include measuring nitrate concentration and counting number of white blood cells. This inexpensive, portable device is also suitable for a variety of other applications, ranging from instant food/water quality examination to long-period environmental monitoring.We tested this lab-on-chip sensing platform under different circumstances and confirmed the results with other commercial analytic testing methods. Even with strip variation and external noise, the sensing platform discussed in this thesis can still produce a fairly accurate result.