Studies of the Relationship Between mRNA Stability and Gene Function in Saccharomyces cerevisiae

Genetics

Moore, Joyce

University:University of Glasgow

关键词: Genetics;   

Others  :  http://theses.gla.ac.uk/77041/1/10983774.pdf

来源: University of Glasgow

【 摘 要 】

Twelve S. cerevisiae cDNAs, characterised by Santiago (1986) on the basis of the half-lifes of the respective mRNAs, have been partially or completely sequenced. To four have been assigned a definite function. cDNA10, which generates a long half-life mRNA, encodes the glucose-inducible form of the glycolytic enzyme, enolase. cDNAs 90, 39 and 13, each of which generates a short half-life mRNA, encode ribosomal proteins L3, L29 and YL6 respectively. cDNA46, which generates a long half-life mRNA, is related to a mouse gene of unknown function, MER5. In addition, there is circumstantial evidence that among the unidentified cDNAs that generate short half-life mRNAs are several that encode ribosomal proteins.