This paper presents the results of the application of CFD to ventilation calculations at Yucca Mountain using MULTIFLUX. Seven cases were selected to study the effect of the heat transport coefficient on the drift wall temperature distribution. It was concluded that variable heat transport coefficients such as those given by the differential-parameter CFD used in MULTIFLUX are considered the most appropriate approach of all cases presented. This CFD model agrees well with FLUENT results and produces the lowest temperature results, which is favorable to ventilation performance.