The Pacific Northwest National Laboratory operates a number of research and development facilities for the U.S. Department of Energy (DOE) in the Hanford Site's 300 Area. The liquid wastes from these facilities are discharged to four liquid effluent systems: the Sanitary Waste System (SNS), the Process Sewer (PS), the Retention Process Sewer (RPS), and the 325 Radioactive Liquid Waste System. The wastewater from the PS and RPS systems is treated by the 300 Area Treated Effluent Disposal Facility and discharged to the Columbia River via a National Pollutant Discharge Elimination System-permitted outfall. The SNS discharges to the City of Richland Publicly Owned Treatment Works under a contract with the DOE. The RLWS wastewater is transported to tanks in the 200 Area. Neither of these two systems interface with the 300 Area TEDF. The following data are provided in this report for each facility involved: a brief, general description of each Pacific Northwest building that discharges liquid waste to the PS or RPS a description of the types of activities that generate the effluent information concerning effluent constituents and the source of this information estimates of flow rates rationale for connections to the RPS.