Bioavailability of Organic Solvents in Soils: Input into Biologically-Based Dose- Response Models for Human Risk Assessments

Wester, Ronald C.

University of California, San Francisco, CA (United States)

关键词: 63 Radiation, Thermal, And Other Environmental Pollutant Effects On Living Organisms And Biological Materials;    Macacus;    Organic Solvents;    Air;    Organic Compounds;   

DOI  :  10.2172/828368
RP-ID  :  EMSP-59828--2000
RP-ID  :  FG07-97ER62509
RP-ID  :  828368

美国|英语

来源: UNT Digital Library

【 摘 要 】

The purpose of this study is to determine the bioavailability of organic solvents following dermal exposures to contaminated soil and water. Breath analysis is being used to obtain real-time measurements of volatile organics in expired air following exposure in rats and humans. Rhesus monkeys were used as surrogates for humans in benzene exposures. The exhaled breath data was analyzed using physiologically based pharmacokinetic (PBPK) models to determine the dermal bioavailability of organic solvents under realistic exposure conditions. The end product of this research will be a tested framework for the rapid screening of real and potential exposures while simultaneously developing PBPK models to comprehensively evaluate and compare exposures to organic compounds from either contaminated soil or water.