Final Progress Report - Grant No.DE-FG02-98ER62558

Smith, T.F.

BMERC, Boston University, Boston, MA (United States)

关键词: Genes;    Functionals;    59 Basic Biological Sciences;    Proteins;    Progress Report;   

DOI  :  10.2172/823570
RP-ID  :  None
RP-ID  :  FG02-98ER62558
RP-ID  :  823570

美国|英语

来源: UNT Digital Library

【 摘 要 】

This final progress report contains a comparison of actual accomplishments with the goals and objectives proposed for the period. It was proposed in the original aims of the proposal that an integrated set of gene sequence/function/structure analysis tools be assembled to support maximal extraction functional information from among the available complete genome Open Reading Frames (ORFs) and their probable regulatory regions. This report lists the progress that was made on these three major components of the proposal: (1) The construction of diagnostic functional patterns/profiles for all probable protein functional domains. (2) The development of methodologies needed to construct full hash tables and associated ORF distributions of all possible regulatory words. The development of sequence comparative tools to search for and identify regulatory circuits among sets of coordinately regulated genes. (3) The construction of prototype data structures, assembled (and updated) from existing databases and other data resources, to support the above developments and their validation.