Protein Model Database

Fidelis, K ; Adzhubej, A ; Kryshtafovych, A ; Daniluk, P

Lawrence Livermore National Laboratory

关键词: Protein Structure;    99 General And Miscellaneous//Mathematics, Computing, And Information Science;    59 Basic Biological Sciences;    Proteins;    Spectroscopy;   

DOI  :  10.2172/15014781
RP-ID  :  UCRL-TR-209958
RP-ID  :  W-7405-ENG-48
RP-ID  :  15014781

美国|英语

来源: UNT Digital Library

【 摘 要 】

The phenomenal success of the genome sequencing projects reveals the power of completeness in revolutionizing biological science. Currently it is possible to sequence entire organisms at a time, allowing for a systemic rather than fractional view of their organization and the various genome-encoded functions. There is an international plan to move towards a similar goal in the area of protein structure. This will not be achieved by experiment alone, but rather by a combination of efforts in crystallography, NMR spectroscopy, and computational modeling. Only a small fraction of structures are expected to be identified experimentally, the remainder to be modeled. Presently there is no organized infrastructure to critically evaluate and present these data to the biological community. The goal of the Protein Model Database project is to create such infrastructure, including (1) public database of theoretically derived protein structures; (2) reliable annotation of protein model quality, (3) novel structure analysis tools, and (4) access to the highest quality modeling techniques available.