Imaging of Isotopically Enhanced Molecular Targeting Agents Final Report

Quong, J N

Lawrence Livermore National Laboratory

关键词: Data Analysis;    Sample Preparation;    37 Inorganic, Organic, Physical And Analytical Chemistry;    Multivariate Analysis;    Chemical Composition;   

DOI  :  10.2172/15009794
RP-ID  :  UCRL-TR-202928
RP-ID  :  W-7405-ENG-48
RP-ID  :  15009794

美国|英语

来源: UNT Digital Library

【 摘 要 】

The goal of this project is to develop experimental and computational protocols to use SIMS to image the chemical composition of biological samples, focusing on optimizing sample preparation protocols and developing multivariate data analysis methods. Our results on sample preparation, molecular imaging, and multivariate analysis have been presented at several meeting abstracts (UCRL151797ABS, UCRL151797ABSREV1, UCRL151426ABS, UCRL201277, UCRL154757). A refereed paper describing our results for sample preparation and molecular imaging of various endogenous biomolecules as well as the mutagen PhIP has been accepted for publication (UCRL-JC-151797). We are also preparing two additional papers describing our multivariate analysis methods to analyze spectral data. As these papers have not been submitted, their content is included in this final report.