APDS: Autonomous Pathogen Detection System

Langlois, R G ; Brown, S ; Burris, L ; Colston, B ; Jones, L ; Makarewicz, T ; Mariella, R ; Masquelier, D ; McBride, M ; Milanovich, F ; Masarabadi, S ; Venkateswaran, K ; Marshall, G ; Olson, D ; Wolcott, D

Lawrence Livermore National Laboratory

关键词: Smoke Detectors;    Pathogens;    Monitoring;    Air;    Nucleic Acids;   

DOI  :  10.2172/15006308
RP-ID  :  UCRL-ID-147224
RP-ID  :  W-7405-ENG-48
RP-ID  :  15006308

美国|英语

来源: UNT Digital Library

【 摘 要 】

An early warning system to counter bioterrorism, the Autonomous Pathogen Detection System (APDS) continuously monitors the environment for the presence of biological pathogens (e.g., anthrax) and once detected, it sounds an alarm much like a smoke detector warns of a fire. Long before September 11, 2001, this system was being developed to protect domestic venues and events including performing arts centers, mass transit systems, major sporting and entertainment events, and other high profile situations in which the public is at risk of becoming a target of bioterrorist attacks. Customizing off-the-shelf components and developing new components, a multidisciplinary team developed APDS, a stand-alone system for rapid, continuous monitoring of multiple airborne biological threat agents in the environment. The completely automated APDS samples the air, prepares fluid samples in-line, and performs two orthogonal tests: immunoassay and nucleic acid detection. When compared to competing technologies, APDS is unprecedented in terms of flexibility and system performance.