A Programmable MicroFluidic Processor: Integrated and Hybrid Solutions

Rose, K A

Lawrence Livermore National Laboratory

关键词: Modifications;    Lawrence Livermore National Laboratory;    Storage;    Testing;    Electrodes;   

DOI  :  10.2172/15006001
RP-ID  :  UCRL-LR-148382
RP-ID  :  W-7405-ENG-48
RP-ID  :  15006001

美国|英语

来源: UNT Digital Library

【 摘 要 】

The Programmable Fluidic Processor (PFP), a device conceived of by researchers at MD Anderson Cancer Center, is a reconfigurable and programmable bio-chemical analysis system designed for handheld operation in a variety of applications. Unlike most microfluidic systems which utilize channels to control fluids, the PFP device is a droplet-based system. The device is based on dielectrophoresis; a fluid transport phenomenon that utilizes mismatched polarizability between a droplet and its medium to induce droplet mobility. In the device, sample carrying droplets are polarized by an array of electrodes, individually addressable by subsurface microelectronics. My research focused on the development of a polymer-based microfluidic injection system for injecting these droplets onto the electrode array. The first of two device generations fabricated at LLNL was designed using extensive research and modeling performed by MD Anderson and Coventor. Fabricating the first generation required several iterations and design changes in order to generate an acceptable device for testing. Difficulties in planar fabrication of the fluidic system and a narrow channel design necessitated these changes. The second generation device incorporated modifications of the previous generation and improved on deficiencies discovered during experimentation with the initial device. Extensive modeling of the injection channels and fluid storage chamber also aided in redesigning the device's microfluidic system. A micromolding technique with interlocking features enabled precise alignments and dimensional control, critical requirements for device optimization. Fabrication of a final device will be fully integrated with the polymer-based microfluidics bonded directly to the silicon-based microelectronics. The optimized design and process flow developed in the trial generations will readily transfer to this approach.