MFISH Measurements of Chromosomal Aberrations Individuals Exposed in Utero to Gamma-ray Doses from 5 to 20 cGy

Brenner, David J.

关键词: mFISH;    in utero;    chromosome aberrations;    gamma ray;   

DOI  :  10.2172/967363
RP-ID  :  DOE-ER63647-Final Report
PID  :  OSTI ID: 967363

学科分类：核能源与工程

美国|英语

来源: SciTech Connect

【 摘 要 】

Our plan was to identify and obtain blood from 36 individuals from the Mayak-in-utero exposed cohort who were exposed in utero only to gamma ray does doses fro 5 to 20 cGy. Our goal is to do mFISH and in a new development, single-arm mFISH on these samples to measure stable chromosome aberrations in these now adult individuals. The results were compared with matched control individuals (same age, same gender) available from the large control population which we are studying in the context of our plutonium worker study. The long term goal was to assess the results both in terms of the sensitivity of the developing embryo/fetus to low doses of ionizing radiation, and in terms of different potential mechanisms (expanded clonal origin vs. induced instability) for an increased risk.