Aneuploidy: a common and early evidence-based biomarker for carcinogens and reproductive toxicants

Environmental Health

Review

Fiorella Belpoggi¹  Daniele Mandrioli¹  Ellen K. Silbergeld²  Melissa J. Perry³ 

[1] Cesare Maltoni Cancer Research Center, Ramazzini Institute, 40010 Bentivoglio, Bologna, Italy;Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 21205, Baltimore, MD, USA;Department of Environmental and Occupational Health, Milken Institute School of Public Health, The George Washington University, 950 New Hampshire Ave. NW, 4th Floor, 20052, Washington, DC, USA;

关键词: Aneuploidy;    Carcinogens;    Reproductive toxicants;    Endocrine disruptors;    Chromosomes;    Early diagnose;    Bioassays;    Risk assessment;    mFISH;    Laser scanning microscopy;   

DOI  :  10.1186/s12940-016-0180-6

 received in 2016-05-21, accepted in 2016-09-28,  发布年份 2016

来源: Springer

【 摘 要 】

Aneuploidy, defined as structural and numerical aberrations of chromosomes, continues to draw attention as an informative effect biomarker for carcinogens and male reproductive toxicants. It has been well documented that aneuploidy is a hallmark of cancer. Aneuploidies in oocytes and spermatozoa contribute to infertility, pregnancy loss and a number of congenital abnormalities, and sperm aneuploidy is associated with testicular cancer. It is striking that several carcinogens induce aneuploidy in somatic cells, and also adversely affect the chromosome compliment of germ cells. In this paper we review 1) the contributions of aneuploidy to cancer, infertility, and developmental abnormalities; 2) techniques for assessing aneuploidy in precancerous and malignant lesions and in sperm; and 3) the utility of aneuploidy as a biomarker for integrated chemical assessments of carcinogenicity, and reproductive and developmental toxicity.

【 授权许可】

CC BY   
© The Author(s). 2016