Wave front migration of endothelial cells in a bone-implant interface

JOURNAL OF BIOMECHANICS

卷:44

Article

Khalil, Georges¹  Lorthois, Sylvie¹  Marcoux, Manuel¹  Mansat, Pierre^1,2  Swider, Pascal¹ 

[1] IMFT UMR CNRS 5502, F-31400 Toulouse, France

[2] Univ Toulouse, Toulouse Univ Hosp, Toulouse, France

关键词: Implant fixation;    Angiogenesis;    Endothelial cells;    Growth factor;    Reactive transport;   

DOI  :  10.1016/j.jbiomech.2011.05.008

来源: Elsevier

【 摘 要 】

The neo-vascularization of the host site is crucial for the primary fixation and the long-term stability of the bone-implant interface. Our aim was to investigate the progression of endothelial cell population in the first weeks of healing. We proposed a theoretical reactive model to study the role of initial conditions, random motility, haptotaxis and chemotaxis in interactions with fibronectin factors and transforming angiogenic factors. The application of governing equations concerned a canine experimental implant and numerical experiments based upon statistical designs of experiments supported the discussion. We found that chemotaxis due to transforming angiogenic factors was attracting endothelial cells present into the host bone. Haptotaxis conditioned by fibronectin factors favored cells adhesion to the host bone. The combination of diffusive and reactive effects nourished the wave front migration of endothelial cells from the host bone towards the implant. Angiogenesis goes together with new-formed bone formation in clinics, so the similarity of distribution patterns of mineralized tissue observed in-vivo and the spatio-temporal concentration of endothelial cells predicted by the model, tended to support the reliability of our theoretical approach. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

Free