Unbalanced expression of VEGF and PEDF in ischemia‐induced retinal neovascularization

FEBS Letters

Gee, Stephen¹  Li, Yan¹  Crosson, Craig¹  Gao, Guoquan¹  Zhang, Dongchang¹  Ma, Jian-xing¹ 

[1] Department of Ophthalmology, Medical University of South Carolina, 167 Ashley Ave., Charleston, SC 29403, USA

关键词: Angiogenesis;    Angiogenic inhibitor;    Diabetic retinopathy;    Growth factor;    Pigment epithelium-derived factor;    Retinal neovascularization;    PEDF;    pigment epithelium-derived factor;    ROP;    retinopathy of prematurity;    VEGF;    vascular endothelial growth factor;   

DOI  :  10.1016/S0014-5793(01)02110-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Retinal levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF), an angiogenic inhibitor, were measured and correlated with the ischemia-induced retinal neovascularization in rats. The retinas with neovascularization showed a 5-fold increase in VEGF while 2-fold decrease in PEDF, compared to the age-matched controls, resulting in an increased VEGF/PEDF ratio. The time course of the VEGF/PEDF ratio change correlated with the progression of retinal neovascularization. Changes in the VEGF and PEDF mRNAs preceded their protein level changes. These results suggest that an unbalance between angiogenic stimulators and inhibitors may contribute to retinal neovascularization.

【 授权许可】

Unknown