The many ways adherent cells respond to applied stretch

JOURNAL OF BIOMECHANICS

卷:49

Article

Sears, Candice¹  Kaunas, Roland¹ 

[1] Texas A&M Univ, Dept Biomed Engn, College Stn, TX 77843 USA

关键词: Cell mechanics;    Cytoskeleton;    Mechanobiology;    Tissue engineering;   

DOI  :  10.1016/j.jbiomech.2015.10.014

来源: Elsevier

【 摘 要 】

Cells in various tissues are subjected to mechanical stress and strain that have profound effects on cell architecture and function. The specific response of the cell to applied strain depends on multiple factors, including cell contractility, spatial and temporal strain pattern, and substrate dimensionality and rigidity. Recent work has demonstrated that the cell response to applied strain depends on a complex combination of these factors, but the way these factors interact to elicit a specific response is not intuitive. We submit that an understanding of the integrated response of a cell to these factors will provide new insight into mechanobiology and contribute to the effective design of deformable engineered scaffolds meant to provide appropriate mechanical cues to the resident cells. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

Free