On the biomechanics of heart valve function

JOURNAL OF BIOMECHANICS

卷:42

Review

Sacks, Michael S.^1,2  Merryman, W. David³  Schmidt, David E.^1,2 

[1] Univ Pittsburgh, Dept Bioengn, Engineered Tissue Mech & Mechanobiol Lab, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, McGowan Inst, Pittsburgh, PA USA

[3] Univ Alabama Birmingham, Dept Biomed Engn, Birmingham, AL 35294 USA

关键词: Heart valves;    Biomechanics;    Soft tissue mechanics;    Cell mechanics;    Mechanobiology;   

DOI  :  10.1016/j.jbiomech.2009.05.015

来源: Elsevier

【 摘 要 】

Heart valves (HVs) are fluidic control components of the heart that ensure unidirectional blood flow during the cardiac cycle. However, this description does not adequately describe the biomechanical ramifications of their function in that their mechanics are multi-modal. Moreover, they must replicate their cyclic function over an entire lifetime, with an estimated total functional demand of least 3 x 10(9) cycles. The focus of the present review is on the functional biomechanics of heart valves. Thus, the focus of the present review is on functional biomechanics, referring primarily to biosolid as well as several key biofluid mechanical aspects underlying heart valve physiological function. Specifically, we refer to the mechanical behaviors of the extracellular matrix structural proteins, underlying cellular function, and their integrated relation to the major aspects of valvular hemodynamic function. While we focus on the work from the author's laboratories, relevant works of other investigators have been included whenever appropriate. We conclude with a summary of important future trends. (C) 2009 Elsevier Ltd. All rights reserved.

【 授权许可】

Free