A Langevin model of physical forces in cell volume fluctuations

JOURNAL OF BIOMECHANICS

卷:49

Article

Zehnder, Steven M.¹  Zegers, Federico M.^1,2  Angelini, Thomas E.^1,3,4 

[1] Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL USA

[2] Univ Florida, Dept Math, Gainesville, FL 32611 USA

[3] Univ Florida, J Crayton Pruitt Family Dept Biomed Engn, Gainesville, FL USA

[4] Univ Florida, Inst Cell & Regenerat Med, Gainesville, FL USA

关键词: Cell mechanics;    Cytoskeleton;    Traction force microscopy;    Cell;    Volume;    Langevin model;   

DOI  :  10.1016/j.jbiomech.2015.12.051

来源: Elsevier

【 摘 要 】

Cells interact mechanically with their physical surroundings by attaching to the extracellular matrix or other cells and contracting the cytoskeleton. Cells do so dynamically, exhibiting fluctuating contractile motion in time. In monolayers, these dynamic contractions manifest as volume fluctuations, which involve the transport of fluid in and out of the cell. An integrated understanding of cell elasticity, actively generated stresses, and fluid transport has not yet been developed. Here we apply a minimal model of these forces to cell volume fluctuation data, elucidating the dynamic behavior of cells within monolayers. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free