Hippocampal subfield volumes and childhood trauma in bipolar disorders

JOURNAL OF AFFECTIVE DISORDERS

卷:253

Article

Janiri, Delfina¹  Sani, Gabriele^2,3,4  De Rossi, Pietro^2,3,5  Piras, Fabrizio⁶  Banaj, Nerisa⁶  Ciullo, Valentina⁶  Simonetti, Alessio^3,5,7  Arciniegas, David B.^7,8  Spalletta, Gianfranco^6,7 

[1] Sapienza Univ Rome, Fac Med & Psychol, Psychiat Residency Training Program, Rome, Italy

[2] Sapienza Univ Rome, St Andrea Hosp, Sch Med & Psychol, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy

[3] Ctr Lucio Bini, Rome, Italy

[4] Tufts Univ, Sch Med, Tufts Med Ctr, Boston, MA 02111 USA

[5] Sapienza Univ Rome, Dept Neurol & Psychiat, Rome, Italy

[6] IRCCS Santa Lucia Fdn, Lab Neuropsychiat, Rome, Italy

[7] Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Div Neuropsychiat, Houston, TX 77030 USA

[8] Univ Colorado, Sch Med, Dept Neurol, Behav Neurol Sect, Aurora, CO USA

关键词: Bipolar disorders;    Hippocampus;    Childhood trauma;    Neuroimaging;    Hippocampal subfields;   

DOI  :  10.1016/j.jad.2019.04.071

来源: Elsevier

【 摘 要 】

Background: Alterations in hippocampal structure and function are present in bipolar disorder (BD). Childhood trauma is associated with risk for BD, and the several subfields of the hippocampus are differentially sensitive to the effects of stressors of the sort associated with risk for BD. The current study therefore sought to test the hypothesis that childhood trauma may be differentially associated with abnormal hippocampal subfield volumes in BD. Methods: 104 participants with BD type I (BD-I, n = 56) or BD type II (BD-II, n = 48) and 81 healthy controls (HC) underwent high-resolution structural magnetic resonance neuroimaging. Hippocampal subfield volumes were determined using FreeSurfer. Childhood trauma was assessed with the Childhood Trauma Questionnaire (CTQ). Results: There were significant effects of diagnosis on intracranial volume corrected hippocampal subfield volumes bilaterally as well as a significant interaction between diagnosis and childhood trauma. Hippocampal volumes did not differ between the BD-I and BD-II subgroups but hippocampal volumes were smaller in both groups when compared to HC. There was a significant effect of childhood trauma on bilateral presubiculum volume as well as significant interactions between diagnosis and childhood trauma on bilateral CA1, presubiculum and subiculum volumes, the direction of which differed between individuals with BD (larger) and HC (smaller). Limitations: Recall bias may influence the reliability of the retrospective assessment of childhood trauma experiences. Conclusions: Childhood trauma demonstrates differential effects on hippocampal subfield volumes of BD and HC, particularly in hippocampal subfields involved in emotion regulation.

【 授权许可】

Free