Childhood maltreatment and metabolic syndrome in bipolar disorders: In search of moderators

PSYCHONEUROENDOCRINOLOGY

卷:131

Article

Godin, Ophelia^1,2  Gaube, Geraud³  Olie, Emilie¹  Belzeaux, Raoul^1,5,6  Bellivier, Frank^1,17  Loftus, Josephine^1,12  Courtet, Philippe^1,7,8  Dubertret, Caroline^1,9  Llorca, Pierre-Michel^1,16  Gard, Sebastien^1,4  Henry, Chantal¹⁰  Schwan, Raymund^1,11  Passerieux, Christine^1,13,14  Polosan, Mircea^1,15  Samalin, Ludovic^1,16  Leboyer, Marion¹  Etain, Bruno^1,17 

[1] Fdn FondaMental, Creteil, France

[2] Univ Paris Est Creteil, Fdn FondaMental, INSERM, IMRB,AP HP,DMU,IMPACT,FHU,ADAPT,Translat Neuropsy, F-94010 Creteil, France

[3] Sorbonne Univ, Hop Tenon, AP HP, Dept Medicouniv Neurosci,Unit Psychiat Psychotrau, Paris, France

[4] Hop Charles Perrens, Ctr Expert Troubles Bipolaires, Serv Psychiat Adulte, Bordeaux, France

[5] AP HM, Pole Psychiat, Marseille, France

[6] Aix Marseille Univ, CNRS, UMR7289, INT, Marseille, France

[7] CHU Montpellier, Lapeyronie Hosp, Dept Emergency Psychiat & Acute Care, Montpellier, France

[8] Univ Montpellier, CHU Montpellier, INSERM, PSNREC, Montpellier, France

[9] Univ Paris, Grp Hosp Univ Nord, Hop Louis Mourier,INSERM,U1266,Fac Med, AP HP,DMU ESPRIT,Serv Psychiat & Addictol,Colombe, Paris, France

[10] GHU Paris Psychiat & Neurosci, Serv Hosp Univ, Dept Psychiat, F-75014 Paris, France

[11] Univ Lorraine, INSERM, U1114, Ctr Psychotherap Nancy, Nancy, France

[12] Ctr Hosp Princesse Grace, Pole Psychiat, Monaco, Monaco

[13] Ctr Hosp Versailles, Serv Univ Psychiat Adultes, Le Chesnay, France

[14] Univ Paris Saclay, UVSQ, INSERM, CESP,Team DevPsy, F-94807 Villejuif, France

[15] Univ Grenoble Alpes, CHU Grenoble & Alpes, Grenoble Inst Neurosci GIN, INSERM,U1216, Grenoble, France

[16] Univ Clermont Auvergne, CHU Clermont Ferrand, Dept Psychiat, EA7280, Clermont Ferrand, France

[17] Univ Paris, GHU St Louis Lariboisiere Fernand Widal, Dept Psychiat & Med Addictol,INSERM,UMRS 1144, Assistance Publ Hop Paris AP HP Paris,DMU Neurosc, Paris, France

关键词: Bipolar disorders;    Childhood trauma;    Childhood maltreatment;    Metabolic syndrome;    Metabolic abnormalities;    CRP;   

DOI  :  10.1016/j.psyneuen.2021.105327

来源: Elsevier

【 摘 要 】

As compared to the general population, adult individuals with bipolar disorders (BD) have higher mortality rates due to cardiovascular diseases and higher prevalence of Metabolic Syndrome (MetS). Recent evidence suggests that childhood maltreatment may contribute to the cardiovascular burden in individuals with BD. However, studies are scarce, with limited sample sizes and inconsistent results. We explored the associations between a selfreported history of childhood maltreatment and MetS (and its subcomponents) in a large sample of 2390 individuals with BD. Childhood maltreatment was assessed using the Childhood Trauma Questionnaire and MetS was defined according to the revised criteria of the ATEP III. We suggested associations between childhood maltreatment and the presence of MetS in men and in younger individuals. The association between childhood maltreatment and the presence of MetS in the early onset subgroup was not significant after adjustment for site of recruitment and level of education. Hence, some links between childhood maltreatment and MetS might exist only in specific subgroups of individuals with BD, but confirmation is required in independent and large samples, while taking into account potential confounders. This would help defining how psychosocial interventions that target childhood maltreatment and its consequences may be beneficial for physical health.

【 授权许可】

Free