Is recurrence in major depressive disorder related to bipolarity and mixed features? Results from the BRIDGE-II-Mix study

JOURNAL OF AFFECTIVE DISORDERS

卷:229

Article

Mazzarini, Lorenzo^1,2  Kotzalidis, Georgios D.¹  Piacentino, Daria¹  Rizzato, Salvatore¹  Angst, Jules^{1,2,3,4,5,6,7,8,9}  Azorin, Jean-Michel⁴  Bowden, Charles L.⁵  Mosolov, Sergey⁶  Young, Allan H.⁷  Vieta, Eduard⁸  Girardi, Paolo¹  Perugi, Giulio⁹ 

[1] Sapienza Univ, Sch Med & Psychol, NESMOS Dept, Rome, Italy

[2] Salvator Mundi Int Hosp, Rome, Italy

[3] Univ Zurich, Hosp Psychiat, Zurich, Switzerland

[4] AP HM, Psychiat Pole, Marseille, France

[5] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA

[6] Moscow Res Inst Psychiat, Dept Therapy Mental Disorders, Moscow, Russia

[7] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, Ctr Affect Disorders, London, England

[8] Univ Barcelona, Hosp Clin, Bipolar Disorders Unit, Clin Inst Neurosci,IDIBAPS,CIBERSAM, Barcelona, Catalonia, Spain

[9] Univ Pisa, Sect Psychiat, Dept Expt & Clin Med, Via Roma 67, I-56100 Pisa, Italy

关键词: Recurrence;    Cyclicity;    Major depressive disorder;    Mixed features;   

DOI  :  10.1016/j.jad.2017.12.062

来源: Elsevier

【 摘 要 】

Background: Current classifications separate Bipolar (BD) from Major Depressive Disorder (MDD) based on polarity rather than recurrence. We aimed to determine bipolar/mixed feature frequency in a large MDD multinational sample with (High-Rec) and without (Low-Rec) > 3 recurrences, comparing the two subsamples. Methods: We measured frequency of bipolarity/hypomanic features during current depressive episodes (MDEs) in 2347 MDD patients from the BRIDGE-II-mix database, comparing High-Rec with Low-Rec. We used Bonferroni-corrected Student's t-test for continuous, and chi-squared test, for categorical variables. Logistic regression estimated the size of the association between clinical characteristics and High-Rec MDD. Results: Compared to Low-Rec (n = 1084, 46.2%), High-Rec patients (n = 1263, 53.8%) were older, with earlier depressive onset, had more family history of BD, more atypical features, suicide attempts, hospitalisations, and treatment resistance and (hypo) manic switches when treated with antidepressants, higher comorbidity with borderline personality disorder, and more hypomanic symptoms during current MDE, resulting in higher rates of mixed depression according to both DSM-5 and research-based diagnostic (RBDC) criteria. Logistic regression showed age at first symptoms< 30 years, current MDE duration <= 1 month, hypomania/ mania among first-degree relatives, past suicide attempts, treatment-resistance, antidepressant-induced swings, and atypical, mixed, or psychotic features during MDE to associate with High-Rec. Limitations: Number of MDEs for defining recurrence was arbitrary; cross-sectionality did not allow assessment of conversion from MDD to BD. Conclusions: High-Rec MDD differed from Low-Rec group for several clinical/epidemiological variables, including bipolar/mixed features. Bipolarity specifier and RBDC were more sensitive than DSM-5 criteria in detecting bipolar and mixed features in MDD.

【 授权许可】

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