H2S-mediated aerobic exercise antagonizes the hippocampal inflammatory response in CUMS-depressed mice

JOURNAL OF AFFECTIVE DISORDERS

卷:283

Review

Liu Ruilian¹  Qu Honglin¹  Xie Jun¹  Long Jianxin¹  Bai Qingyun²  Chen Yilin¹  Mao Haifeng¹ 

[1] Yichun Univ, Coll Phys Educ, Yichun 336000, Jiangxi, Peoples R China

[2] Yichun Univ, Coll Chem & Bioengn, Jiangxi Key Lab Nat Drug Res, Yichun 336000, Jiangxi, Peoples R China

关键词: Chronic stress stimulated depression model;    Hippocampus;    Hydrogen sulfide;    Inflammatory;    Aerobic exercise;   

DOI  :  10.1016/j.jad.2021.02.005

来源: Elsevier

【 摘 要 】

Purpose: This thesis was to investigate the protective effect and mechanism of H2S-mediated aerobic exercise on the antagonism of the hippocampus inflammatory response in CUMS-depressed mice. Method: Seventy C57BL/6 mice were randomly divided into control group (CG), model control group (MG), model exercise group (ME), H2S enhanced group (HG) and H2S enhanced and exercise group (HE). All mice except CG underwent a 28-day CUMS depression model. ME and HE received moderate-intensity aerobic treadmill training for 8 weeks. They were randomly selected for Nissl staining, Immunofluorescence, methylene blue colorimetric assay, and ELISA. The levels of IL-10 and TNF-alpha were detected by qRT-PCR, and the expression levels of CBS and inflammatory-related factors in the hippocampus were detected. Result: Compared with CG, the number of erections, modifications, and crossing grids in MG mice were significantly reduced, the time of forced swimming and forced tail suspension was significantly prolonged, the positive rate of 5-HT decreased, and the symptoms of depression were obvious. The positive rate of CD45+ increased, the inflammatory response was obvious, and the content of H2S and the expression of biosynthetic enzyme CBS decreased. Aerobic exercise and H2S-enhanced mice improved depressive symptoms, decreased proinflammatory factors, increased anti-inflammatory factors, increased H2S content, increased CBS expression, and increased H2S. Conclusion: H2S may participate in aerobic exercise to antagonize the inflammatory process of the hippocampus in CUMS-depressed mice by reducing the release of inflammatory response factors and hippocampus nerve injury factors, and effectively alleviate inflammatory injury in the hippocampus of depressed mice.

【 授权许可】

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