Depression and serum low-density lipoprotein: A systematic review and meta-analysis

JOURNAL OF AFFECTIVE DISORDERS

卷:206

Review

Persons, Jane E.^1,2  Fiedorowicz, Jess G.^1,2,3,4 

[1] Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Iowa City, IA USA

[2] Univ Iowa, Dept Psychiat, Carver Coll Med, Iowa City, IA 52242 USA

[3] Univ Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA

[4] Univ Iowa, Carver Coll Med, Francois M Abboud Cardiovasc Res Ctr, Iowa City, IA USA

关键词: Depression;    Low-density lipoprotein;    Meta-analysis;    Lipids;    Cholesterol;   

DOI  :  10.1016/j.jad.2016.07.033

来源: Elsevier

【 摘 要 】

Background: A cross-sectional association between depression and serum low-density lipoprotein (LDL) has been noted in the literature. This study aims to employ meta-analytic techniques to clarify the relationship between depression and serum LDL. Methods: Published articles through April 2015 were identified through systematic query of PubMed with follow-up manual searches. Data from 36 studies reporting mean difference and 7 studies reporting odds ratios were analyzed separately. Results: Meta-analysis of studies modeling serum LDL as a continuous measure demonstrates overall significantly lower serum LDL in depression (Mean difference= -4.29, 95% CI= -8.19, 0.40, p=0.03). Meta-analysis of studies modeling serum LDL as a categorical measure demonstrates a marginally significant lower odds of depression in the presence of low serum LDL relative to high serum LDL (OR= 0.90, 95% CI=0.80, 1.01, p=0.08). Limitations: High heterogeneity was noted across sampled studies, which may be a function of variations in study design, participants sampled, or other factors. The potential for publication bias was also assessed. Conclusions: This meta-analysis demonstrates a cross-sectional link between depression and low serum LDL. (C) 2016 Elsevier B.V. All rights reserved.

【 授权许可】

Free