Composite lipid indices in patients with obstructive sleep apnea: a systematic review and meta-analysis

Lipids in Health and Disease

Research

Zahra Shokri Varniab¹  Pegah Bahiraie²  Laleh Foroutani³  Amir Hossein Behnoush⁴  Amirmohammad Khalaji⁴ 

[1] Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran;Pediatric Urology and Regenerative Medicine Research Center, Gene, Cell and Tissue Research Institute, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran;School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran;

关键词: Lipids;    Obstructive sleep apnea;    Atherogenic index of plasma;    Lipid accumulation product;    Visceral adiposity index;    Systematic review;    Meta-analysis;   

DOI  :  10.1186/s12944-023-01859-3

 received in 2023-05-22, accepted in 2023-06-23,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundOne of the most prevalent sleep disorders affecting the individual’s daily life is obstructive sleep apnea (OSA), for which obesity is a major risk factor. Several novel lipid indices have been suggested to have associations with OSA, among which visceral adiposity index (VAI), atherogenic index of plasma (AIP), and lipid accumulation product (LAP) are the most important ones. Herein, the current study aimed to systematically investigate the association between these indices and OSA.MethodsFour international databases, including PubMed, Scopus, the Web of Science, and Embase were searched in order to find relevant studies that investigated LAP, VAI, or AIP in OSA and compared them with non-OSA cases or within different severities of OSA. Random-effect meta-analysis was used to generate the standardized mean difference (SMD) and 95% confidence interval (CI) of the difference in lipid indices between OSA and non-OSA cases. Moreover, the pooled area under the receiver operating characteristic curves (AUCs) observed in individual studies for diagnosis of OSA based on these lipid indices were calculated by random-effect meta-analysis.ResultsTotally 14 original studies were included, comprised of 14,943 cases. AIP, LAP, and VAI were assessed in eight, five, and five studies, respectively. Overall, these lipid indices had acceptable diagnostic ability (AUC 0.70, 95% CI 0.67 to 073). Meta-analysis revealed that AIP was significantly higher in patients with OSA (SMD 0.71, 95% CI 0.45 to 0.97, P < 0.01). Moreover, AIP also increased in higher severities of OSA. Regarding LAP, a higher LAP was observed in OSA/patients with high risk for OSA rather than in controls/low risk for OSA (SMD 0.53, 95% CI 0.25 to 0.81, P < 0.01). VAI was also increased in OSA based on results from two studies.ConclusionThese findings suggest that composite lipid indices are increased in OSA. Also, these indices can have the potential beneficiary diagnostic and prognostic ability in OSA. Future studies can confirm these findings and enlighten the role of lipid indices in OSA.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

40517_2023_252_Article_IEq117.gif

40517_2023_252_Article_IEq115.gif

40517_2023_252_Article_IEq112.gif

40517_2023_252_Article_IEq107.gif

40517_2023_252_Article_IEq103.gif