Micro/nanofabricated platforms for oral drug delivery

JOURNAL OF CONTROLLED RELEASE

卷:219

Article

Fox, Cade B.¹  Kim, Jean^2,3  Le, Long V.^2,3  Nemeth, Cameron L.^2,3  Chirra, Hariharasudhan D.¹  Desai, Tejal A.^1,2,3 

[1] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94158 USA

[2] Univ Calif Berkeley, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Grad Program Bioengn, San Francisco, CA 94158 USA

关键词: Microfabrication;    Nanofabrication;    Oral drug delivery;    Microdevice;    Nanotopography;    Targeted delivery;   

DOI  :  10.1016/j.jconrel.2015.07.033

来源: Elsevier

【 摘 要 】

The oral route of drug administration is most preferred due to its ease of use, low cost, and high patient compliance. However, the oral uptake of many small molecule drugs and biotherapeutics is limited by various physiological barriers, and, as a result, drugs suffer from issues with low solubility, low permeability, and degradation following oral administration. The flexibility of micro- and nanofabrication techniques has been used to create drug delivery platforms designed to address these barriers to oral drug uptake. Specifically, micro/nanofabricated devices have been designed with planar, asymmetric geometries to promote device adhesion and unidirectional drug release toward epithelial tissue, thereby prolonging drug exposure and increasing drug permeation. Furthermore, surface functionalization, nanotopography, responsive drug release, motion-based responses, and permeation enhancers have been incorporated into such platforms to further enhance drug uptake. This review will outline the application of micro/nanotechnology to specifically address the physiological barriers to oral drug delivery and highlight technologies that may be incorporated into these oral drug delivery systems to further enhance drug uptake. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

Free