Towards nanomedicines of the future: Remote magneto-mechanical actuation of nanomedicines by alternating magnetic fields

JOURNAL OF CONTROLLED RELEASE

卷:219

Article

Golovin, Yuri I.^1,2  Gribanovsky, Sergey L.¹  Golovin, Dmitry Y.¹  Klyachko, Natalia L.^2,4  Majouga, Alexander G.^2,3  Master, Alyssa M.⁴  Sokolsky, Marina⁴  Kabanov, Alexander V.^2,4 

[1] GR Derzhavin Tambov State Univ, Nanoctr, Tambov 392000, Russia

[2] Moscow MV Lomonosov State Univ, Fac Chem, Lab Chem Design Bionanomat, Moscow 117234, Russia

[3] Natl Univ Sci & Technol MISiS, Moscow 119049, Russia

[4] Univ N Carolina, Eshelman Sch Pharm, Ctr Nanotechnol Drug Delivery, Chapel Hill, NC 27599 USA

关键词: Nanomedicine;    Alternating magnetic field;    Magnetic nanoparticles;    Magneto-mechanical actuation;   

DOI  :  10.1016/j.jconrel.2015.09.038

来源: Elsevier

【 摘 要 】

The paper describes the concept of magneto-mechanical actuation of single-domain magnetic nanoparticles (MNPs) in super-low and low frequency alternating magnetic fields (AMFs) and its possible use for remote control of nanomedicines and drug delivery systems. The applications of this approach for remote actuation of drug release as well as effects on biomacromolecules, biomembranes, subcellular structures and cells are discussed in comparison to conventional strategies employing magnetic hyperthermia in a radio frequency (RF) AMF. Several quantitative models describing interaction of functionalized MNPs with single macromolecules, lipid membranes, and proteins (e.g. cell membrane receptors, ion channels) are presented. The optimal characteristics of the MNPs and an AMF for effective magneto-mechanical actuation of single molecule responses in biological and bio-inspired systems are discussed. Altogether, the described studies and phenomena offer opportunities for the development of novel therapeutics both alone and in combination with magnetic hyperthermia. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

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