PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application

JOURNAL OF CONTROLLED RELEASE

卷:260

Review

Grossen, Philip¹  Witzigmann, Dominik¹  Sieber, Sandro¹  Huwyler, Jorg¹ 

[1] Univ Basel, Div Pharmaceut Technol, Dept Pharmaceut Sci, Basel, Switzerland

关键词: Nanomedicine;    Nanoparticle;    Polymer;    Peg-PCL;    Drug delivery;    Drug targeting;   

DOI  :  10.1016/j.jconrel.2017.05.028

来源: Elsevier

【 摘 要 】

The lack of efficient therapeutic options for many severe disorders including cancer spurs demand for improved drug delivery technologies. Nanoscale drug delivery systems based on poly( ethylene glycol)-poly(epsilon-caprolactone) copolymers (PEG-PCL) represent a strategy to implement therapies with enhanced drug accumulation at the site of action and decreased off-target effects. In this review, we discuss state-of-the-art nanomedicines based on PEG-PCL that have been investigated in a preclinical setting. We summarize the various synthesis routes and different preparation methods used for the production of PEG-PCL nanoparticles. Additionally, we review physico-chemical properties including biodegradability, biocompatibility, and drug loading. Finally, we highlight recent therapeutic applications investigated in vitro and in vivo using advanced systems such as triggered release, multi-component therapies, theranostics, or gene delivery systems.

【 授权许可】

Free