Stimuli-responsive prodrug-based cancer nanomedicine

EBioMedicine

Na Kong¹  Na Yoon Kim²  Sumaira Hanif³  Wei Tao⁴  Zhongmin Tang⁴  Bingyang Shi⁴  Dylan Patel⁴  Angel Xie⁴  Baowen Qi⁴  Jiang Ouyang⁵ 

[1] College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China;Corresponding authors.;Singapore American School, Singapore, 738547;Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA;Henan-Macquarie Uni Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China;

关键词: Cancer therapy;    Nanomedicine;    Prodrug;    Stimuli-responsive;    Polymer;   

DOI  :  

来源: DOAJ

【 摘 要 】

The rapid development of nanotechnology results in the emergence of nanomedicines, but the effective delivery of drugs to tumor sites remains a great challenge. Prodrug-based cancer nanomedicines thus emerged due to their unique advantages, including high drug load efficiency, reduced side effects, efficient targeting, and real-time controllability. A distinctive characteristic of prodrug-based nanomedicines is that they need to be activated by a stimulus or multi-stimulus to produce an anti-tumor effect. A better understanding of various responsive approaches could allow researchers to perceive the mechanism of prodrug-based nanomedicines effectively and further optimize their design strategy. In this review, we highlight the stimuli-responsive pathway of prodrug-based nanomedicines and their anticancer applications. Furthermore, various types of prodrug-based nanomedicines, recent progress and prospects of stimuli-responsive prodrug-based nanomedicines and patient data in the clinical application are also summarized. Additionally, the current development and future challenges of prodrug-based nanomedicines are discussed. We expect that this review will be valuable for readers to gain a deeper understanding of the structure and development of prodrug-based cancer nanomedicines to design rational and effective drugs for clinical use.

【 授权许可】

Unknown