Poly(para-phenyleneethynylene)s: probing the biological interface with biomolecular materials

Polymer;Biosensor;Nanoparticle;Fluorescence;Bacteria;Assays

Phillips, Ronald Lee, III ; Chemistry and Biochemistry

University:Georgia Institute of Technology

Department:Chemistry and Biochemistry

关键词: Polymer;    Biosensor;    Nanoparticle;    Fluorescence;    Bacteria;    Assays;   

Others  :  https://smartech.gatech.edu/bitstream/1853/26555/1/phillips_ronnie_l_200812_phd.pdf

美国|英语

来源: SMARTech Repository

【 摘 要 】

The synthesis and biological sensing applications of novel water soluble poly(para-phenyleneethynylene)s (PPEs) are presented.The ease of synthesis, synthetic variability, and dramatic chromicity of PPEs makes them well suited for biological and sensing applications.Molecular recognition and signal transduction can be achieved by using PPEs as sensory materials.By incorporating biological functional groups (e.g. sugars), PPEs can efficiently detect the presence of toxic heavy metals, proteins, and bacteria through either fluorescence quenching or enhancement.Rapid, precise, and convenient sensory arrays for the detection of biological analytes are possible through the formation of gold nanoparticle-PPE constructs.