Therapeutic and diagnostic applications of extracellular vesicles

JOURNAL OF CONTROLLED RELEASE

卷:244

Article; Proceedings Paper

Stremersch, Stephan¹  De Smedt, Stefaan C.¹  Raemdonck, Koen¹ 

[1] Univ Ghent, Fac Pharmaceut Sci, Lab Gen Biochem & Phys Pharm, Ottergemsesteenweg 460, B-9000 Ghent, Belgium

关键词: Extracellular vesicles;    Exosomes;    Drug delivery;    Biomarker;    Vaccination;    Diagnostics;   

DOI  :  10.1016/j.jconrel.2016.07.054

来源: Elsevier

【 摘 要 】

During the past two decades, extracellular vesicles (EVs) have been identified as important mediators of intercellular communication, enabling the functional transfer of bioactive molecules from one cell to another. Consequently, it is becoming increasingly clear that these vesicles are involved in many (patho) physiological processes, providing opportunities for therapeutic applications. Moreover, it is known that themolecular composition of EVs reflects the physiological status of the producing cell and tissue, rationalizing their exploitation as biomarkers in various diseases. In this review the composition, biogenesis and diversity of EVs is discussed in a therapeutic and diagnostic context. We describe emerging therapeutic applications, including the use of EVs as drug delivery vehicles and as cell-free vaccines, and reflect on future challenges for clinical translation. Finally, we discuss the use of EVs as a biomarker source and highlight recent studies and clinical successes. (C) 2016 Elsevier B.V. All rights reserved.

【 授权许可】

Free